Solutions for the Interaction of MCA with Immune Cells

Relying on the technology platform of the tumor microenvironment center, Alfa Cytology provides comprehensive solutions for study the interaction between MSCs and immune cells in TME, helping researchers to successfully achieve their research goals.

Introduction

Numerous studies have confirmed that mesenchymal stem cells (MSCs) influence the local immune environment by releasing various cytokines and also participate in the regulation of intercellular communication signals between immune cells (antigen-presenting cells, T cells, B cells, natural killer cells, etc.) through direct contact with immune cells, regulating both innate and adaptive immunity and ultimately contributing to the down-regulation of local inflammatory responses and reducing tissue inflammatory damage. MSCs interact with various immune cells, but the specific mechanisms involved are not well understood.

Then, it is clear whether bone marrow mesenchymal stem cells (MSCs), which are carriers of tumor therapy, are affected by the cytokines, signaling molecules and immune cell interactions in the tumor microenvironment (TME) and undergo tumor transformation by themselves, and the exact mechanism by which they exert immunomodulation and the safety of their clinical application need to be further explored and deepened.

Solutions

In the complex tumor microenvironment, mesenchymal stem cells regulate various cells of the immune system, and interact and interact with immune cells. Therefore, revealing the molecular mechanism and regulatory mechanism of the interaction between mesenchymal stem cells and immune cells in the tumor microenvironment will help to improve the effectiveness of tumor immunotherapy / MSCs therapy. Alfa Cytology has established an innovative tumor microenvironment central technology platform and is developing multiple technologies to study the interaction mechanism between mesenchymal stem cells (MSCs) and immune cells in TME, providing new ideas for drug development for clinical tumor therapy and new targets.

Key technologies

To further explore the complex mechanisms of interaction between cells and their microenvironment (cell-to-cell and even cell-to-extracellular matrix) in a three-dimensional state, Alfa Cytology provides 3D co-culture model, a more reliable and convenient tool. Using a novel three-dimensional (3D) co-culture model to study the interaction of tumor mesenchymal stem cells (MSCs) with immune cells can better reflect their status in the in vivo microenvironment. Also, combining flow cytometry or conventional histological tests such as electron microscopy (SEM), fluorescence microscopy, semi-thin sections and immunohistochemical (HC) observations, or measuring the expression of relevant markers, can further explore the interaction between tumor MSCs and immune cells and make some contributions to the development of anticancer agents and the search for biomarkers.

Alfa Cytology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.