Molecular Characterization Services for Cancer Metastasis in TME

Molecular characterization plays a critical role in understanding cancer metastasis within the tumor microenvironment (TME). This area of research holds tremendous potential for enhancing cancer diagnosis, prognosis, and treatment. At Alfa Cytology, we are committed to advancing the understanding of cancer metastasis by providing high-quality molecular characterization services.

Molecular Characterization of Cancer Metastasis in TME

The process of cancer metastasis is intricate, involving the spread of cancer cells from the primary tumor to different regions of the body. The metastatic capacity of cancer cells is significantly influenced by the TME. Within the TME, certain immune cells have the capability to identify and eliminate cancer cells, while others may promote their survival and dissemination. Moreover, acellular elements present in the TME, such as the extracellular matrix (ECM) and signaling molecules, also contribute significantly to the facilitation of cancer metastasis. Signaling molecules have the potential to stimulate the epithelial-mesenchymal transition (EMT), a process that increases the mobility and invasiveness of cancer cells. Advancements in molecular profiling techniques have enabled the identification of specific genetic and epigenetic alterations associated with metastasis. By analyzing these molecular features, researchers can potentially identify biomarkers for early detection of metastatic disease and develop targeted therapies tailored to inhibit metastatic processes.

Fig. 1 Pharmaceutical regulation of the TME at various stages of the metastatic process. (Neophytou CM, et al, 2021)

Molecular Characterization Services for Cancer Metastasis in TME

Alfa Cytology offers specialized molecular characterization services for the comprehensive analysis of cancer metastasis in the TME. Our services include, but are not limited to:

• Assessing Metastasis-related Proteins in TME
  We employ immunohistochemistry (IHC) to visualize and quantify the protein expression in tissue samples. By using specific antibodies, we can support our clients assessing the expression levels and localization of key proteins involved in cancer metastasis within the TME, such as markers of epithelial-mesenchymal transition (EMT) or angiogenesis.
• Visualizing Gene Expression in TME
  In Situ Hybridization (ISH) enables the detection and localization of specific RNA molecules within tissue samples. We employ this technique to examine the expression of genes involved in metastasis, such as oncogenes or metastasis-associated genes, providing spatial information about their expression patterns within the TME.
• Decoding Metastasis and Tumor Heterogeneity in TME
  We utilize next-generation sequencing (NGS) to characterize the genetic landscape of metastatic tumors in patients with various cancer types. Thus, we can help our clients identify key genetic alterations associated with metastasis and reveal the heterogeneity of tumor cells within the TME.
• Identifying Metastatic Biomarkers for Early Cancer Detection
  Accurate identification and characterization of metastatic biomarkers are vital for early detection and prognosis of cancer metastasis. We employ liquid biopsy and circulating tumor cells (CTCs) analysis to identify specific genetic alterations and molecular signatures associated with metastatic potential.
• Multi-Omics Integration for Metastasis Analysis
  We employ an integrated approach that incorporates multi-omics data, such as genomics, transcriptomics, and proteomics, to provide a comprehensive characterization of the TME in various cancer types. Our analysis supports researchers uncovering novel molecular subtypes and identifying key signaling pathways that are closely linked to the process of metastasis.

The Advantages of Our Molecular Characterization Services

• By leveraging IHC, ISH, NGS, and other methodologies, we are equipped to deliver our clients exhaustive and intricate understanding of the molecular dynamics of cancer metastasis within the TME.
• Our multidisciplinary approach allows us to tackle complex research questions and provide comprehensive molecular characterization services tailored to the unique needs of each client.
• We are skilled in data analysis, interpretation, and visualization, ensuring that our clients receive meaningful and actionable insights from their molecular characterization results.

At Alfa Cytology, we leverage these research methods and more to offer a range of molecular characterization services for cancer metastasis in the TME. Our team of experts is well-versed in their application and interpretation. We are committed to providing you with comprehensive insights into the molecular mechanisms of cancer metastasis, enabling advancements in diagnosis, prognosis, and targeted therapies. Contact us today for your molecular characterization needs and join us in our mission to unravel the mysteries of cancer metastasis.

Reference

1. Neophytou CM, et al. The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities. Cancers (Basel), 2021;13(9):2053.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.