Solutions for TAM Immunomodulation in TME

Relying on the technology platform of the tumor microenvironment center, Alfa Cytology provides global collaborators with solutions and related services to study the relationship between tumor immunity and tumor-associated macrophages (TAM) in the tumor microenvironment (TME), helping them to rapidly achieve their research goals.

Introduction

Tumor-associated macrophages (TAM), macrophages that evolve from infiltration of peripheral blood mononuclear cells into solid tumor tissue, account for a large proportion of tumor stromal cells and are receiving increasing attention. It is a heterogeneous cell population that exhibits a variety of phenotypes depending on the type of tumor and its location in the tumor microenvironment (TME). It is mainly considered to have pro-tumorigenic effects. In addition to pro-angiogenic and metastatic effects, these include immunosuppressive effects. However, how TAM is specifically formed, how the phenotypic changes of TAM are regulated, what is the relationship between the biological behavior of tumor cells and TAM, and how TAM exerts its immunomodulatory effects. These questions are still not clearly answered. Therefore, elucidating the molecular mechanisms of functional changes of macrophages in the microenvironment will likely provide new clues for future tumor biotherapy.

Solutions

Previously, tumor-associated macrophages (TAM) were thought to be important anti-tumor effector cells that could either directly kill tumor cells or induce an immune response by presenting tumor-associated antigens to clear tumors. However, in recent years, more and more studies have shown that TAM do not exert anti-tumor effects directly, but act indirectly on tumor-associated stroma or endothelial cells by secreting specific cytokines and growth factors. Further, it is involved in processes such as pro-tumor development, stimulation of tumor cell growth and metastasis, induction of tumor neovascularization and lymphangiogenesis, and immunosuppression. These have suggested to researchers that TAM may be a new target for human intervention in the treatment of tumors. In-depth study of TAM has the potential to thoroughly elucidate the mechanisms of tumor immune tolerance and explore effective immunotherapeutic approaches.

Alfa Cytology has established a tumor microenvironment technology platform and developed several emerging technologies through which it helps global collaborators to deeply explore the relationship between tumor immunity and tumor-associated macrophages (TAM) in the tumor microenvironment (TME), hoping to find potential targets for tumor therapy in the process and provide new ideas for clinical anti-tumor treatment.

Key technologies

TAM plays an important role in the processes of tumorigenesis and development and immune regulation, which can be manifested in several aspects. TAM has become a target for antitumor immunotherapy, and the mechanism of TAM-tumor cell interaction and TAM in tumor immune regulation has become a hot topic of research in recent years, but there is a lack of an ideal TAM cell model. Alfa Cytology is developing an emerging TAM cell model based on its own tumor microenvironment technology center platform, which more realistically simulates TAM in the tumor microenvironment, in order to provide you with services for TAM-related research.

Alfa Cytology offers flow cytometry, ELISA, hoechst staining and other techniques that are classical methods for studying tumor immunity. Combined with these techniques, experiments are performed from various aspects/perspectives to elucidate the molecular mechanisms of functional changes of tumor-associated macrophages (TAM) in the microenvironment and how they exert immune regulatory functions.

Alfa Cytology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.