Imaging Services for Inflammatory Responses
Relying on the technology platform of the tumor microenvironment center, Alfa Cytology provides a full range of services of imaging of inflammatory response in the tumor microenvironment (TME) to help scientific researchers successfully achieve their research goals.
Introduction
As early as the middle of the 19th century, the German pathologist Rudolf Virchow discovered a large infiltration of inflammatory cells in tumour tissue and proposed the conjecture that tumours originated from chronic inflammation. It is now clear to the medical community that inflammation is closely related to cancer development, progression and the efficacy of anti-cancer treatment. For example, gastric cancer is associated with H. pylori infection, nasopharyngeal cancer with herpes virus infection, and liver cancer with hepatitis virus infection; systemic inflammation, such as obesity and depression, is also associated with tumour incidence and poor efficacy of anti-cancer treatment; and treatment-induced inflammatory responses also affect the clinical outcome of tumours to varying degrees. Although some anti-inflammatory drugs (aspirin, statins) can significantly reduce the incidence of cancer and the risk of death, some pro-inflammatory cytokines or stimulants (TNF-α, cGAS-STING pathway activators) can promote the infiltration of immune cells into infected tissues and thus significantly improve the efficacy of tumour treatment, suggesting that inflammation is a "double-edged sword This suggests that inflammation is a "double-edged sword".
Services
Alfa Cytology provides imaging services designed to help clients resolve issues related to inflammatory response in the tumor microenvironment. Our imaging services include, but are not limited to:
Inflammatory processes are finely tuned systems, with many molecular signals that orchestrate the immune response. For most conditions, it is probable that only limited diagnostic information will be obtained by one or two blood-derived inflammatory markers. The potential strength of molecular imaging is to 'see' into the core of the inflammatory site, targeting multiple biomarkers (multiplexing) to provide a deeper insight into the triggers, cellular interplay, pro- versus anti-inflammatory mediators and the ability to evaluate current and the next generation of therapies for chronic immune diseases with a level of precision and detail not seen before. Implementing molecular imaging, therefore, can uncover new information on disease processes which can in turn offer new targets for disease diagnosis and stratification.
After intravenous injection, 67Ga is bound to transferrin and transported to the site of inflammation to localise the aggregates in the inflammatory lesion.
Adherence to the vascular endothelium due to a mechanism of increased expression of local adhesion molecules in inflammation. Subsequently, they migrate through the endothelium and basement membrane by a process of cellular exudation and by chemotaxis to the inflammatory lesion. The site of the inflammatory lesion can be revealed by in vitro detection of the radioactive distribution.
- PET imaging service
- CT imaging service
- MRI imaging service
- Image fusion service, such as combining anatomical images with molecular images.
Note: Our services list is constantly being updated and improved, please contact us by email for more up-to-date and relevant information.
Alfa Cytology offers a wide selection of technologies for imaging inflammatory responses in the tumour microenvironment (TME) to help you study the many challenges associated with inflammatory reactivity in the tumour microenvironment. Multiplex imaging has great potential for application in studying the mechanisms of diseases where changes in tumour and inflammatory responsiveness are pathological features.
Advantages
- Our platform equipment is advanced, with a number of world and domestic leading large / high-end instruments and equipment, and a number of world-leading technologies independently developed.
- We have a high-end technical team, who have been deeply involved in imaging technology for many years, with comprehensive knowledge, skills and rich experience, and strictly control the quality of data.
- We have a variety of cooperation models and can provide a full range of scientific research or project development cooperation and services.
Alfa Cytology is dedicated to supporting scientists in making groundbreaking scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. We have established the tumor microenvironment center technology platform with high performance scientific instruments and high value solutions to ensure high quality services that enable scientists to explore the mysteries of life at the tumor microenvironment level. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.