Solutions for Exosomal Immunomodulation in TME

Relying on the technology platform of the tumor microenvironment center, Alfa Cytology provides global collaborators with solutions and related services to study the relationship between tumor immunity and exosomes in the tumor microenvironment (TME), helping them to rapidly achieve their research goals.

Introduction

The dynamic network of non-malignant cells, non-cellular components, signaling molecules and extracellular matrix (ECM) surrounding the tumor together form a composition known as the tumor microenvironment (TME). One of the key components of the tumor microenvironment (TME) is the immune cells. Exosomes are a double-edged sword in the TME. Cancer cells can regulate immune cells through exosomes to promote tumor growth and survival; conversely, immune cells can activate the immune response in the TME through exosomes to inhibit tumor cell growth. Exosomes play an important role in the mutual regulation of tumor and immune cells, and there is an increasing interest in the study of exosome function in the tumor immune microenvironment.

Solutions

Exosomes play an important role in the process of mutual regulation of tumor and immune cells, and the study of exosome function in tumor immune microenvironment has received increasing attention. To address this process, Alfa Cytology has established a tumor microenvironment technology platform and developed several emerging technologies and assembled a large amount of protocol experience and experimental tools to elaborate a one-stop exosome tumor immunology functional services. The services include: identification of tumor immune donor cells and recipient cells, immune phenotype analysis, tumor immune exosome isolation and modification, tumor immune exosome function verification, etc., which comprehensively analyze the exosome function and mechanism of action of tumor cells and immune cells in various tumor immune processes.

Key technologies

Alfa Cytology identifies tumor immune donor cells and recipient cells through sample flow analysis, in vivo mouse exosome tracing, and in vitro cellular exosome uptake assays.

Alfa Cytology performs immunophenotypic analysis through immune cell-specific target flow assays, immunofluorescence, immunohistochemistry, cellular and exosomal PD-L1 assays, and other experimental techniques.

Alfa Cytology performs tumor immune exosome isolation and modification by experimental techniques such as immune cell sorting, immune cell cell line construction, primary cell stable cell line construction, cell 3D culture and exosome isolation, and exosome function verification.

Alfa Cytology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.