Analysis of Cellular Components in TME

In the tumor microenvironment (TME), a diverse array of cellular components interact with one another and engage with cancer cells. At Alfa Cytology, we recognize the crucial significance of analyzing cellular components within the TME to unveil the intricacies of cancer advancement and discover viable therapeutic targets.

Cellular Components in TME

Developing effective cancer therapies requires a comprehensive understanding of TME's cellular components and functions. Cancer-associated fibroblasts (CAFs), a crucial cellular component, have the ability to reshape the extracellular matrix, offering structural reinforcement to the tumor. Additionally, they contribute to immune evasion and therapy resistance. While immune cells such as T cells, natural killer cells (NK cells), and dendritic cells within the TME attempt to eliminate cancer cells at the initial stages of tumorigenesis, cancer cells ultimately evade immune surveillance and suppress cytotoxic abilities of tumor-antagonistic immune cells through diverse mechanisms. Moreover, myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) have an immunosuppressive effect, which contributes to the progression of cancer.

Fig. 1 Impact of immune cells within the tumor microenvironment. (Anderson NM, et al., 2020)

Analysis of Cellular Components in TME

Alfa Cytology specializes in providing a detailed analysis of these cellular components in the TME. Our services include, but are not limited to:

• T Cell Biology Services in TME
  We provide a wide range of services tailored to the study of T cell anergy, exhaustion, senescence, and stemness in the TME.
• Phenotypical and Functional Heterogeneity Analysis of CAFs in TME
  We offer comprehensive characterization services to unravel the diverse characteristics of CAF subsets and their functional implications.
• Analysis of Macrophage Polarization in TME
  We offer advanced assays to evaluate macrophage polarization and provide valuable insights into their phenotypic and functional states.
• Analysis of NK Cell Dysfunction in TME
  We provide our customers with comprehensive analysis of NK cell dysfunction in the TME to unravel the intricate interactions between NK cells and the TME.
• Immunosuppressive Effect Analysis of Dendritic Cells in TME
  We provide a variety of specialized services to offer comprehensive insights and tailored strategies in studying the immunosuppressive effect of dendritic cells in the tumor microenvironment.
• Analysis of Neutrophil Functions in TME
  We offer researchers a comprehensive set of neutrophil assays to uncover the intricate mechanisms and functions of neutrophils within the TME.
• Analysis of MDSC-Mediated Immune Suppression in TME
  We offer a range of advanced services focused on analyzing MDSC-mediated immune suppression within the TME to investigate the intricate world of MDSCs and their significant impact on cancer progression.

At Alfa Cytology, we utilize advanced techniques to decipher the intricate interplay between cellular components in the tumor microenvironment. Our profound expertise plays a pivotal role in aiding our clients to formulate targeted therapeutic strategies. Contact us today to learn more about our services and how we can help you unravel the complexities of the tumor microenvironment.

Reference

1. Anderson NM, et al. The tumor microenvironment. Curr Biol, 2020, 30(16): R921-R925.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.